Muguruza used her experience to get out of trouble, eventually set up a meeting with Ukrainian 10th seed Elina Svitolina in just over two hours under a relentless sun at Indian Wells.
Wimbledon will naturally miss an old favourite with Rafael Nadal sidelined by injury yet Garbine Muguruza, armed with her sunny demeanour and blistering talent, seems perfectly happy and equipped to fill the void left by her great Spanish compatriot.
Former men's champion Mats Wilander believes third seed Muguruza now looks like the most likely champion, having not dropped a set and thrashing Maria Sharapova on Wednesday.
Images from Day 2 of the French Open in Paris on Monday.
Spain's Garbine Muguruza insists she is enjoying herself at the French Open even if she doesn't look it, but don't expect her to smile too much until she gets her hands on the Suzanne Lenglen trophy for the second time in three years.
Spain's Garbine Muguruza, one of the rising stars of women's tennis, beat Switzerland's Timea Bacsinszky to win the China Open on Sunday, her biggest title to date.
Garbine Muguruza has to be the one taking charge in the Australian Open final against "fighter" Sofia Kenin if she is to win her third Grand Slam title, the Spaniard's coach Conchita Martinez said.
Garbine Muguruza was relieved to finally avoid tripping at the last hurdle and end her trophy drought
Garbine Muguruza stormed back into the Grand Slam big time with a 7-5, 6-3 win over Russian Anastasia Pavlyuchenkova to reach her first Australian Open semi-final. Fourth seed Simona Halep advanced to her second Australian Open semi-final with a 6-1, 6-1 demolition of Estonia's Anett Kontaveit in just 53 minutes on Rod Laver Arena.
21-year-old Garbine Muguruza has already proved that she has the power and intelligence to reduce the all-conquering American to a nervous wreck when she subjected Serena Williams to a 6-2, 6-2 pummelling at last year's French Open.
Venus Williams will try to become the oldest woman to win Wimbledon for 109 years on Saturday although, ominously for her the last time a 37-year-old reached the final, it was a Spaniard who ruined the script.
American Sofia Kenin counter-punched her way back from a set down against Garbine Muguruza to win her first Grand Slam title at the Australian Open with a 4-6, 6-2, 6-2 win in Melbourne on Saturday. The 21-year-old Kenin, seeded 14th at Melbourne Park, converted her second matchpoint against the twice Grand Slam champion, who double faulted on the final point, to end an engrossing contest that lasted more than two hours.
Olympic champion and world number one Serena Williams tumbled out of the Rio de Janeiro singles competition in the third round on Tuesday after a shock defeat to Ukraine's Elina Svitolina.
Former world number one Venus Williams salvaged a small bit of family pride when she fought back from a set down to see off Italy's Roberto Vinci 5-7, 6-2, 7-6(4)and reach the final of the Wuhan Open on Friday.
A look at the records of Garbine Muguruza and Sofia Kenin ahead of their Australian Open final on Saturday.
Spain's Garbine Muguruza successfully defended her Monterrey Open title on Sunday when Victoria Azarenka retired injured from her first WTA singles final in three years.
Agnieszka Radwanska rallied past an exhausted Garbine Muguruza to book her place in the WTA Finals title decider on Saturday with a 6-7(5), 6-3, 7-5 victory over the Spanish prospect in a classic encounter.
Spain's Garbine Muguruza moved to the brink of the WTA Finals last four with a 6-4, 6-4 win over Angelique Kerber on Wednesday after Petra Kvitova opened her account with a 7-5, 7-5 victory over fellow Czech Lucie Safarova.
IMAGES from the matches played on Day 10 of the BNP Paribas Open at Indian Wells, California, on Wednesday
Spanish fourth seed Garbine Muguruza fine-tuned her preparations for this month's U.S. Open by crushing Simona Halep 6-1, 6-0 in the Cincinnati Open final on Sunday.
List of Wimbledon women's singles champions after Iga Swiatek beat Amanda Anisimova in the final on Saturday:
'When she hits her peak she's so dangerous because she moves well.'
Garbine Muguruza continued her dream debut at the WTA Finals by completing round robin play with a perfect 3-0 record to advance to the semi-finals after a hard fought 6-4, 4-6, 7-5 victory over Petra Kvitova on Friday.
She will now play Dutch 15th seed Kiki Bertens, who saw off Australian qualifier Daria Gavrilova 6-3, 6-3, in Saturday's semi-final on the red Foro Italico clay.
Anett Kontaveit handed Czech Karolina Pliskova a 6-4, 6-0 drubbing to become the first player to qualify for the semi-finals while Garbine Muguruza came from behind to defeat Barbora Krejcikova 2-6, 6-3, 6-4 at the WTA Finals in Guadalajara, Mexico on Friday.
A summary of sports events and sports persons, who made news on Monday
The 23-year-old Wimbledon champion, who climbed to the top of the WTA rankings on Monday, hardly broke sweat against the Frenchwoman, ranked 20th in the world, on her way to victory in an hour and 20 minutes.
David Ferrer sent local favourite Bernard Tomic packing with an easy 6-3, 7-5 win in the opening round of the Brisbane International on Monday.
A heady mix of talent and gumption, Garbine Muguruza now in the same league as Arantxa-Sanchez Vicario
Novak Djokovic kept his juggernaut rolling at the China Open by improving to 26-0 with a 6-2, 6-1 win over local hope Zhang Ze on Thursday.
Women's tennis's biggest names still remaining at the US Open take centre stage on Sunday with Grand Slam winners Maria Sharapova, Venus Williams, Garbine Muguruza and Petra Kvitova all appearing on Arthur Ashe Stadium.
Former champion Garbine Muguruza suffered a second consecutive first-round exit at the French Open
PHOTOS from day seven of the Wimbledon championships at the All England Lawn Tennis in London on Tuesday.
Agnieszka Radwanska paid the ultimate price for following the orders of her coaching team rather than relying on her own instincts in the final game of her Wimbledon semi-final against Garbine Muguruza on Thursday.
With only two weeks to go for the Australian Open, tennis stars Roger Federer, Victoria Azarenka, Radek Stepanek and Garbine Muguruza were seen in a light-spirited mood in Brisbane. As part of Nickelodeon Kids Day, the tennis stars led by 17-time Grand Slam winner Roger Federer posed for pictures with cartoon characters.
Venus Williams captured her 47th WTA career title on Saturday, and her biggest in five years, when she won the Wuhan Open in China, beating Wimbledon runner-up Garbine Muguruza.
Be it cheering for Roger Federer or Garbine Muguruza at the Wimbledon final, the Hollywood brigade made their presence felt at both, the women's and men's final at Wimbledon over the weekend. We caught a few cine stars watching their tennis heroes in action at the All England Club...
Belinda Bencic of Switzerland and Danielle Collins were among those to win their first-round matches at the Adelaide International
Wimbledon champion Garbine Muguruza suffered a 6-2, 6-4 defeat at the hands of unseeded Czech Barbora Strycova in the second round of the Nature Valley Classic in Birmingham on Thursday.
Images from Day 5 of the Wimbledon tennis championships played in London, on Friday.